Choice of bacteria in animal models of sepsis
نویسندگان
چکیده
منابع مشابه
Animal models of sepsis
Sepsis remains a common, serious, and heterogeneous clinical entity that is difficult to define adequately. Despite its importance as a public health problem, efforts to develop and gain regulatory approval for a specific therapeutic agent for the adjuvant treatment of sepsis have been remarkably unsuccessful. One step in the critical pathway for the development of a new agent for adjuvant trea...
متن کاملPathogenesis of Epilepsy: Challenges in Animal Models
Epilepsy is one of the most common chronic disorders affecting individuals of all ages. A greater understanding of pathogenesis in epilepsy will likely provide the basis fundamental for development of new antiepileptic therapies that aim to prevent the epileptogenesis process or modify the progression of epilepsy in addition to treatment of epilepsy symptomatically. Therefore, severa...
متن کاملAnimal Models for Sepsis Research
Edison P Reyes1,2, Paula P Cortés3 and Ricardo Fernández3* 1Centro de Fisiología Celular e Integrativa, Facultad de Medicina, Clínica Alemana-Universidad del Desarrollo, Chile 2Dirección de Investigación, Universidad Autónoma de Chile, Chile 3Departamento de Salud, Universidad de Los Lagos, Chile *Corresponding author: Ricardo Fernández, Departamento de Salud, Universidad de Los Lagos. Av. Fuch...
متن کاملAnimal models of sepsis and sepsis-induced kidney injury.
Sepsis is characterized by a severe inflammatory response to infection, and its complications, including acute kidney injury, can be fatal. Animal models that correctly mimic human disease are extremely valuable because they hasten the development of clinically useful therapeutics. Too often, however, animal models do not properly mimic human disease. In this Review, we outline a bedside-to-ben...
متن کاملThe disconnect between animal models of sepsis and human sepsis.
Frequently used experimental models of sepsis include cecal ligation and puncture, ascending colon stent peritonitis, and the i.p. or i.v. injection of bacteria or bacterial products (such as LPS). Many of these models mimic the pathophysiology of human sepsis. However, identification of mediators in animals, the blockade of which has been protective, has not translated into clinical efficacy i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1993
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.61.7.2741-2747.1993